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Laminin L4 domain structure resembles adhesion modules in ephrin receptor and other transmembrane glycoproteins.

FEBS J.. 2015; 
MoranToot,GatYair,FassDeb
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Codon Optimization Synthetic genes encoding human L4 domains, codon‐optimized for expression in Escherichia coli, were purchased from GenScript (Piscataway, NJ, USA),  Get A Quote

摘要

The ~ 800 kDa laminin heterotrimer forms a distinctive cross-shaped structure that further self-assembles into networks within the extracellular matrix. The domains at the laminin chain termini, which engage in network formation and cell-surface interaction, are well understood both structurally and functionally. By contrast, the structures and roles of additional domains embedded within the limbs of the laminin cross have remained obscure. Here, we report the X-ray crystal structure, determined to 1.2 Å resolution, of the human laminin α2 subunit L4b domain, site of an inframe deletion mutation associated with mild congenital muscular dystrophy. The α2 L4b domain is an irregular β-sandw... More

关键词

carbohydrate-binding module,domain,ephrin,extracellular matrix,lam