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Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model.

Xenotransplantation. 2013; 
BradyJamie L,SutherlandRobyn M,HancockManuela,KitsoulisSusie,LahoudMireille H,PhillipsPeta M,HawthorneWayne J,d'ApiceAnthony J F,CowanPeter J,HarrisonLeonard C,O'ConnellPhilip J,LewAndr
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Codon Optimization … The codon optimized DNA was synthesized by GenScript (GenScript USA Inc., Piscataway,NJ, USA) as a single multi‐gene cassette utilizing the furin/F2A 'ribosomal skip' signal to combine the heavy and light chain sequences 21. CD5L‐hIgG3 … Get A Quote

摘要

We investigated whether graft produced anti-human CD2, mediated by adenovirus (Adv) transduction of pig neonatal islet cell clusters (pNICC), would protect xenografts in a humanized mouse model from immune attack and whether such immunosuppression would remain local.

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