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DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9
Authors: Ya-Jing Shi , Min Duan , Jun-Mei Ding , Fan-Qi Wang , Li-Li Bi , Cai-Xiang Zhang , Yi-Zhou Zhang , Jun-Yi Duan , An-Hui Huang , Xin-Lin Lei , Hao Yin , Ying Zhang
Journal: Mol Cell
PubMed ID: 36272409
Doi: 10.1016/j.molcel.2022.09.032
Products & Services: Bacterial Expression   Gene Synthesis   
Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity
Authors: Adrian A Valli, Irene Gonzalo-Magro, Diego H Sanchez
Journal: Mol Biol Evol
PubMed ID: 36322467
Doi: 10.1093/molbev/msac240
Products & Services: Gene Synthesis   
Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells
Authors: Stephanie Ubiparipovic, Daniel Christ, Romain Rouet
Journal: Protein Eng Des Sel
PubMed ID: 36336952
Doi: 10.1093/protein/gzac011
Products & Services: Gene Synthesis   
An odorant receptor that senses four classes of musk compounds
Authors: Keiichi Yoshikawa, Jun Deguchi, Hu Jieying, Hsiu-Yi Lu, Hiroaki Matsunami
Journal: Curr Biol
PubMed ID: 36370695
Doi: 10.1016/j.cub.2022.10.038
Products & Services: Gene Synthesis   
Retinal regions shape human and murine Müller cell proteome profile and functionality
Authors: Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Journal: Glia
PubMed ID: 36334068
Doi: 10.1002/glia.24283
Products & Services: Gene Synthesis   
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells
Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez
Journal: Endocrinology
PubMed ID: 36320101
Doi: 10.1210/endocr/bqac185
Products & Services: Gene Synthesis   
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses
Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen
Journal: Bioorg Chem
PubMed ID: 36395603
Doi: 10.1016/j.bioorg.2022.106264
Products & Services: Gene Synthesis   
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice
Authors: Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven
Journal: Pancreatology
PubMed ID: 36379850
Doi: 10.1016/j.pan.2022.11.003
Products & Services: Gene Synthesis   
Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections
Authors: Catherine B Blackwood, Margalida Mateu-Borrás, Emel Sen-Kilic, Gage M Pyles, Sarah Jo Miller, Kelly L Weaver, William T Witt, Annalisa B Huckaby, Jason Kang, Courtney E Chandler, Robert K Ernst, F Heath Damron, Mariette Barbier
Journal: npj Vaccines
PubMed ID: 36357402
Doi: 10.1038/s41541-022-00562-1
Products & Services: Gene Synthesis   
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Authors: Madhuvanthi Kannan, Ganesh Vasan, Simon Haziza, Cheng Huang, Radosław Chrapkiewicz, Junjie Luo, Jessica A Cardin, Mark J Schnitzer, Vincent A Pieribone
Journal: Science
PubMed ID: 36378956
Doi: 10.1126/science.abm8797
Products & Services: Gene Synthesis   

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