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Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing

Authors: Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman

Journal: Mol Cancer

PubMed ID: 37365642

Doi: 10.1186/s12943-023-01799-7

Products & Services: Proteins, Expression, Isolation and Analysis

Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression

Authors: Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang

Journal: Cell Mol Life Sci

PubMed ID: 37369919

Doi: 10.1007/s00018-023-04838-0

Products & Services: Proteins, Expression, Isolation and Analysis

CLDN182 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN182-expressing tumor-directed T-cell activation

Authors: Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z Zhang, Andrew X Zhu, Lin Shen

Journal: J Immunother Cancer

PubMed ID: 37364935

Doi: 10.1136/jitc-2023-006704

Products & Services: Proteins, Expression, Isolation and Analysis

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Journal: biorxiv

PubMed ID: 37333273

Doi: 10.1101/2023.06.01.543353

Products & Services: Proteins, Expression, Isolation and Analysis

Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies

Authors: Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai

Journal: Sci Rep

PubMed ID: 37380701

Doi: 10.1038/s41598-023-37288-6

Products & Services: Proteins, Expression, Isolation and Analysis

The role of mechano-regulated YAP/TAZ in erectile dysfunction

Authors: Mintao Ji, Dongsheng Chen, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang, Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang, Yongde Xu, Lei Chang

Journal: Nat Commun

PubMed ID: 37353497

Doi: 10.1038/s41467-023-39009-z

Products & Services: Proteins, Expression, Isolation and Analysis

Performance of commercial SARS-CoV-2 wild-type and Omicron BA1 antibody assays compared with pseudovirus neutralization tests

Authors: E Habermann, L M Frommert, K Ghannam, L Nguyen My, L Gieselmann, P Tober-Lau, J Klotsche, A N Arumahandi de Silva, A Ten Hagen, J Zernicke, F Kurth, L E Sander, F Klein, G R Burmester, R Biesen, F N Albach

Journal: J Clin Virol

PubMed ID: 37354690

Doi: 10.1016/j.jcv.2023.105518

Products & Services: Proteins, Expression, Isolation and Analysis

Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways

Authors: Seong Jae Han, Hyemi Lee, Jiho Nam, Cheol-Ho Pan, Jimin Jeon, Siyoung Yang

Journal: J Cell Mol Med

PubMed ID: 37337779

Doi: 10.1111/jcmm.17814

Products & Services: Proteins, Expression, Isolation and Analysis

The putative role of the epipeptide EpeX in intra-species competition

Authors: Margarita Kalamara, James Abbott, Tetyana Sukhodub, Cait MacPhee, Nicola R Stanley-Wall