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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals
Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean
Journal: Antiviral Res
PubMed ID: 38548023
Doi: 10.1016/j.antiviral.2024.105869
Products & Services: Molecular Biology Reagents   
Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice
Authors: Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh
Journal: AAPS PharmSciTech
PubMed ID: 38472523
Doi: 10.1208/s12249-024-02778-x
HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel
Journal: Nat Commun
PubMed ID: 38499535
Doi: 10.1038/s41467-024-46538-8
Products & Services: Molecular Biology Reagents   
A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges
Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2
Journal: Adv Mater
PubMed ID: 38145557
Doi: 10.1002/adma.20231088
Products & Services: Plasmid DNA Preparation   
LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms
Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao
Journal: Microb Cell Fact
PubMed ID: 38528536
Doi: 10.1186/s12934-024-02359-4
Products & Services: Molecular Biology Reagents   
Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan
Journal: Science
PubMed ID: 38484052
Doi: 10.1126/science.adn7272
Products & Services: Gene Synthesis   
An intein-based biosensor to measure protein stability in vivo
Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon
Journal: Protein Sci
PubMed ID: 38380775
Doi: 10.1002/pro.4925
Products & Services: Gene Synthesis   
MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis 
Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1
Journal: Nucleic Acids Research
PubMed ID: 38520410
Doi: 10.1093/nar/gkae193
Products & Services: Peptide Synthesis   
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells
Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng
Journal: Nature
PubMed ID: 38480774
Doi: 10.1038/s41598-024-56681-3
Products & Services: Polyclonal Antibody Services   
Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD
Authors: Tianyu Hu, Xiaolin Yang, Yuanchen Zhu, Fengjiang Liu, Xiuna Yang, Zhiqi Xiong, Jingxi Liang, Zhenli Lin, Yuting Ran, Luke W Guddat, Zihe Rao, Bing Zhang
Journal: SCIENCE ADVANCES
PubMed ID: 38507491
Doi: 10.1126/sciadv.adk8521

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