GenScript (USA), #RP10245 and RP10008-5, respective- ly. Human recombinant GDNF was from ThermoFisher Scientific (PHC7045). ... ">
至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Effect of GDNF on Morphology, Proliferation, and Phagocytic Activity of Rat Neonatal Cortex Isolated Microglia.

Bionanoscience.. 2016-08; 
M Zhuravleva, A Rizvanov, Y Mukhamedshina.
Products/Services Used Details Operation

摘要

Microglia are the main defenders of the central nervous system and at the same time are involved in the pathogenesis of various neurological disorders. Microglia hyperactivity or phagocytic impairment exacerbates degenerative processes in nervous tissue leading to further loss of function. A variety of factors and cytokines may modify microglia function. In our study, it was shown that glial cell line-derived neurotrophic factor (GDNF), a well-known neuroprotective molecule, decreases phagocytic activity of microglia in vitro model of spinal cord injury. Recombinant adenovirus encoding GDNF (Ad5-GDNF) transfected microglia have shown the same effect and can be potentially used as a therapeutic agent in case of ... More

关键词

Microglia; Glial cell line-derived neurotrophic factor; Recombinant adenovirus