Arachidonic acid (ARA， C20:4， n-6)， which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities， is commercially produced in Mortierella alpina. Dissolved oxygen or oxygen utilization efficiency is a critical factor for Mortierella alpina growth and arachidonic acid production in large-scale fermentation. Overexpression of the Vitreoscilla hemoglobin gene is thought to significantly increase the oxygen utilization efficiency of the cells.
Arachidonic acid (ARA， C20:4， n-6)， which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities， is commercially produced in Mortierella alpina. Dissolved oxygen or oxygen utilization efficiency is a critical factor for Mortierella alpina growth and arachidonic acid production in large-scale fermentation. Overexpression of the Vitreoscilla hemoglobin gene is thought to significantly increase the oxygen utilization efficiency of the cells.
