Improving acetyl-CoA biosynthesis in via the overexpression of pantothenate kinase and PDH bypass

Acetyl-CoA is an important precursor in . Various approaches have been adopted to improve its cytosolic level previously with the emphasis on engineering the "acetyl-" part of acetyl-CoA. To the best of our knowledge， there have been no reports on engineering the "-CoA" part so far.

Acetyl-CoA，Naringenin production，Pantothenate，Pantothenate kinase，Pyruvate dehydrogenase bypass，Saccharomyces cerevi