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Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy.

Microb. Cell Fact.. 2019-05; 
WangCaixia,SuXinyao,SunMengchu,ZhangMengting,WuJiajia,XingJianmin,WangYing,XueJianping,LiuXia,SunWei,ChenSh
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Codon Optimization To improve gene expression in S. cerevisiae we optimized the codons CYP88D6 (OP-CYP88D6) and CYP72A154 (OP-CYP72A154) for genes cloning into pUC57, which were synthesized by GenScript (GenScript, Nanjing, China). Get A Quote

摘要

Glycyrrhetinic acid (GA) is the most important ingredient in licorice due to its outstanding anti-inflammatory activity and wide application in the medicine and cosmetics industries. Contemporary industrial production of GA by acid hydrolysis of glycyrrhizin which was extracted from Glycyrrhiza plants, is not environment-friendly and devastates farmland since the Glycyrrhiza rhizomes grow up to 10 m underground.

关键词

Glycyrrhetinic acid,Metabolic engineering,Saccharomyces cerevisiae,Triter