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Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.

Antiviral Res.. 2013-06; 
Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT. Division of Infectious Disease, School of Medicine, University of California San Diego. 9500 Gilman Drive, La Jolla, CA 92093, United Sates of America; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology. 9420 Athena Circle, La Jolla, CA 92037, United States of America; School of Veterinary Medicine, National Taiwan University. No. 1, Sec. 4 Roosevelt Road, Taipei 10617, Taiwan.
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摘要

An influenza pandemic poses a serious threat to humans and animals. Conventional treatments against influenza include two classes of pathogen-targeting antivirals: M2 ion channel blockers (such as amantadine) and neuraminidase inhibitors (such as oseltamivir). Examination of the mechanism of influenza viral infection has shown that endosomal acidification plays a major role in facilitating the fusion between viral and endosomal membranes. This pathway has led to investigations on vacuolar ATPase (v-ATPase) activity, whose role as a regulating factor on influenza virus replication has been verified in extensive genome-wide screenings. Blocking v-ATPase activity thus presents the opportunity to interfere with inf... More

关键词

Influenza virus; Vacuolar ATPase inhibitor; Diphyllin; Oseltamivir; Amantadine