| Products/Services Used | Details | Operation |
|---|---|---|
| Gene Synthesis | These genes were synthesized by Genscript with appropriate flanking restriction enzyme sites, subcloned into a single two-segment mammalian expression vector, and used to transfect CHO-S cells (Invitrogen) for stable co-expression of protein complex and selection of high | Get A Quote |
The role of T cells in controlling human cancers is well known. Their success requires continued persistence in vivo and efficient trafficking to tumor sites, requirements shared by other effectors such as Natural Killer (NK) cells. To date, cytokine IL2 remains the only clinically approved cytokine therapy available to expand, maintain, and activate these effector lymphoid cells, but toxicities can be severe. Cytokine IL15 offers similar T cell proliferation and activation properties, but without the unwanted side-effects seen with IL2. Several IL15-cytokine fusion proteins have been developed to improve their in vivo function, typically exploiting the IL15R?? to complex with IL15, to extend serum half-life an... More
