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Minimalist Nanovaccine with Optimized Amphiphilic Copolymers for Cancer Immunotherapy

ACS Nano .. 2024-01; 
Le Niu , Yu Miao , Zhiqin Cao , Ting Wei , Jiafei Zhu , Maoyi Li , Boxiong Bai , Linfu Chen , Nanhui Liu , Feng Pan , Junjie Zhu , Cheng Wang , Yang Yang , Qian Chen
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Peptide Synthesis Model antigenic peptides OVA257−280 (SIINFEKLTEWTSSNVMEERKIKV) and FITC-OVA257−280 were synthesized by GenScript. Get A Quote

摘要

Cancer vaccines with the ability to elicit tumor-specific immune responses have attracted significant interest in cancer immunotherapy. A key challenge for effective cancer vaccines is the spatiotemporal codelivery of antigens and adjuvants. Herein, we synthesized a copolymer library containing nine poly(ethylene glycol) methyl ether methacrylate-co-butyl methacrylate-co-2-(azepan-1-yl)ethyl methacrylate (PEGMA-co-BMA-co-C7AMA) graft copolymers with designed proportions of different components to regulate their properties. Among these polymers, C-25, with a C7AMA:BMA ratio at 1.5:1 and PEG wt % of 25%, was screened as the most effective nanovaccine carrier with enhanced ability to induce mouse bone marrow-deriv... More

关键词

Cancer vaccine; Copolymer library; Immune checkpoint blockade; Immunotherapy; Minimalist nanovaccine.