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Modulatory role of copper on hIAPP aggregation and toxicity in presence of insulin

Int J Biol Macromol. 2023-04; 
Dipanwita Roy, Narayan Chandra Maity, Sourav Kumar, Anupam Maity, Bhisma N Ratha, Ranjit Biswas, Nakul Chandra Maiti, Atin Kumar Mandal, Anirban Bhunia
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Peptide Synthesis … Chemicals and solvents were obtained from Sigma Aldrich, USA. Synthetic unlabelledhIAPP peptides were purchased from GenScript (Piscataway, USA). hIAPP was dissolved in HFIP, … Get A Quote

摘要

Aggregation of the human islets amyloid polypeptide, or hIAPP, is linked to β-cell death in type II diabetes mellitus (T2DM). Different pancreatic β-cell environmental variables such as pH, insulin and metal ions play a key role in controlling the hIAPP aggregation. Since insulin and hIAPP are co-secreted, it is known from numerous studies that insulin suppresses hIAPP fibrillation by preventing the initial dimerization process. On the other hand, zinc and copper each have an inhibitory impact on hIAPP fibrillation, but copper promotes the production of toxic oligomers. Interestingly, the insulin oligomeric equilibrium is controlled by the concentration of zinc ions when the effect of insulin and zinc has bee... More

关键词

Copper, Insulin, Nuclear magnetic resonance, Toxic oligomer, Type II diabetes mellitus, hIAPP