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Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide

Int J Appl Basic Med Res. 2023-07; 
Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay
Products/Services Used Details Operation
Peptide Synthesis … The biotinylated DV1 peptide used in this study was synthesized by GenScript with the sequence (D)L(D)G(D)A(D)S(D)W(D)H(D)R(D)P(D)D(D)K-CCLGYQKRPLP-GGSGK (7), MW … Get A Quote

摘要

unassigned: Chemokine receptor CXCR4 is frequently present in cells of various cancers. Hence, targeted therapy using CXCR4 ligands, such as DV1 peptide, on drug-loaded nanoparticles, has the potential to enhance the efficiency of cancer treatment. unassigned: The present study created a CXCR4-targeting drug delivery system using avidin-poly (lactic-co-glycolic acid) (PLGA) nanoparticle surface tagged with biotinylated DV1 peptide ligand. unassigned: A double-emulsion solvent evaporation technique was employed to prepare avidin-PLGA nanoparticles and characterized by transmission electron microscopy (TEM) and dynamic light scattering. Uptake was studied by confocal microscopy after incorporating fluorescein iso... More

关键词

CXCR4 receptors, Cancer therapeutics, DV1 peptide, poly(lactic-co-glycolic acid) nanoparticles