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The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells

J Immunol. 2023-05; 
David L Bauer, Louay Bachnak, Vanessa M Limbert, Rebecca M Horowitz, Robin L Baudier, Shaina J D'Souza, Victoria E Immethun, Jonathan R Kurtz, Samuel B Grant, James B McLachlan
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Peptide Synthesis … 2W1S peptide (sequence EAWGALANWAVDSA) was purchased as sterile and endotoxin free from GenScript Biotech and resuspended at 4 mg/ml in sterile Dulbecco’s PBS (Life … Get A Quote

摘要

Adjuvants are often essential additions to vaccines that enhance the activation of innate immune cells, leading to more potent and protective T and B cell responses. Only a few vaccine adjuvants are currently used in approved vaccine formulations in the United States. Combinations of one or more adjuvants have the potential to increase the efficacy of existing and next-generation vaccines. In this study, we investigated how the nontoxic double mutant Escherichia coli heat-labile toxin R192G/L211A (dmLT), when combined with the TLR4 agonist monophosphoryl lipid A (MPL-A), impacted innate and adaptive immune responses to vaccination in mice. We found that the combination of dmLT and MPL-A induced an expansion of ... More

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