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Increasing insight in the value of repetitive COVID-19 vaccination in patients with haematological malignancies in the Omicron era

Br J Haematol. 2023-11; 
Ulrike Bacher, Evgenii Shumilov, Thomas Pabst
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摘要

The study by Kevlicius et al. from Lithuania gives further confirmation of the efficacy of booster mRNA COVID-19 vaccination for patients with haemato-oncological malignancies in the Omicron era. The risk of COVID-19 and mortality was considerably reduced when patients received the booster vaccination. The threshold of the humoral response to vaccination that was protective for haemato-oncological patients was defined. In particular, ruxolitinib and anti-CD20 treatments limited the humoral response to the third booster vaccination. These data may influence the clinical management of haemato-oncological patients in future waves of the COVID-19 pandemic, regarding for example the selection of patients for passiv... More

关键词

Omicron, haematologic malignancies, repetitive COVID-19 vaccination