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Adenoviral-vectored epigraph vaccine elicits robust, durable, and protective immunity against H3 influenza A virus in swine

Front Immunol. 2023-05; 
Erika Petro-Turnquist, Matthew Pekarek, Nicholas Jeanjaquet, Cedric Wooledge, David Steffen, Hiep Vu, Eric A Weaver
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Peptide Synthesis … Briefly, flat-bottomed 96-well plates (Immunolon 4 HBX; VWR) were coated overnight at 4C … /11SW87/2011 HA protein was synthesized by Genscript as individual 17-mer peptides with … Get A Quote

摘要

Current methods of vaccination against swine Influenza A Virus (IAV-S) in pigs are infrequently updated, induce strain-specific responses, and have a limited duration of protection. Here, we characterize the onset and duration of adaptive immune responses after vaccination with an adenoviral-vectored Epigraph vaccine. In this longitudinal study we observed robust and durable antibody responses that remained above protective titers six months after vaccination. We further identified stable levels of antigen-specific T cell responses that remained detectable in the absence of antigen stimulation. Antibody isotyping revealed robust class switching from IgM to IgG induced by Epigraph vaccination, while the commerci... More

关键词

adenoviral (Ad) vector, duration, epigraph, pathology, swine influenza, transmission, vaccine