| Products/Services Used | Details | Operation |
|---|---|---|
| Molecular Biology Reagents | … Peptides were synthesized by GenScript, dissolved in distilled water at 10 −2 M, stored at −20 C, and diluted in ASW prior to usage. They were bath applied from at least 2 h prior to the … | Get A Quote |
Food intake is regulated by internal state. This function is mediated by hormones and neuropeptides, which are best characterized in popular model species. However, the evolutionary origins of such feeding-regulating neuropeptides are poorly understood. We used the jellyfish to address this question. Our combined transcriptomic, behavioral, and anatomical approaches identified GLWamide as a feeding-suppressing peptide that selectively inhibits tentacle contraction in this jellyfish. In the fruit fly , myoinhibitory peptide (MIP) is a related satiety peptide. Surprisingly, we found that GLWamide and MIP were fully interchangeable in these evolutionarily distant species for feeding suppression. Our results sugge... More
