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High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma

PeerJ. 2023-10; 
Wei Fei, Yan Yan, Guangjun Liu, Bo Peng, Yuanyuan Liu, Qiang Chen
Products/Services Used Details Operation
Recombinant Proteins … loss-of-function assays revealed that FAM83A promoted cell … FOXM1 cDNA, which was synthesized by Genscript (the … LUAD cell lines and normal human alveolar epithelial cells … Get A Quote

摘要

background: According to the histopathology, lung adenocarcinoma (LUAD) could be divided into five distinct pathological subtypes, categorized as high-risk (micropapillary and solid) group, intermediate-risk (acinar and papillary) group, and low-risk (lepidic) group. Despite this classification, there is limited knowledge regarding the role of transcription factors (TFs) in the molecular regulation of LUAD histology patterns. methods: Publish data was mined to explore the candidate TFs associated with high-risk histopathology in LUAD, which was validated in tissue samples. Colony formation, CCK8, EdU, transwell, and matrigel assays were performed to determine the biological function of FAM83A . Subcutaneous tum... More

关键词

FAM83A, Histological pathology subtype, LUAD, Transcription factors