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Nullomer peptide increases immune cell infiltration and reduces tumor metabolism in triple negative breast cancer mouse model

Res Sq. 2023-06; 
Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian
Products/Services Used Details Operation
Peptide Synthesis Drug preparation- 9S1R nullomer peptide (sequence RRRRRWCMNW) was synthesized by Genscript (USA) (lyophilyzed, HPLC purified, purity > 98%) and stored at − 20 ◦C. For preparation of 9S1R-NulloPT, briefly, 20 µg/µl stock solution of the 9S1R peptide was prepared in 100mM Trehalose (Sigma-Aldrich, USA), which was then used as mg/kg body weight for injections in mice. Get A Quote

摘要

Background: Nullomers are the shortest strings of absent amino acid (aa) sequences in a species or group of species. Primes are those nullomers that have not been detected in the genome of any species. 9S1R is a 5-aa peptide derived from a prime sequence that is tagged with 5 arginine aa, used to treat triple negative breast cancer (TNBC) in an in vivo TNBC mouse model. 9S1R is administered in trehalose (9S1R-NulloPT), which enhances solubility and exhibits some independent effects against tumor growth and is thus an important component in the drug preparation. Method: We examined the effect of 9S1R-NulloPT on tumor growth, metabolism, metastatic burden, necrosis, tumor immune microenvironment, and the trans... More

关键词

TNBC; breast cancer; nullomer; peptide; triple negative breast cancer; tumor microenvironment.