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A network pharmacological approach for the identification of potential therapeutic targets of - a complex traditional Siddha formulation

J Biomol Struct Dyn. 2024-03; 
Agnes Preethy H, Yanamandram Balasubramanian Venkatakrishnan, Vigneshwar Ramakrishnan, Uma Maheswari Krishnan
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摘要

(BN), a traditional Indian polyherbal formulation has been described in classical texts for the treatment of anxiety and depression, as well as to fortify the immune system. The individual herbs of BN have been used for treatment of wide range of disorders including cognition, inflammation, skin ailments and cancer etc., This diverse basket of therapeutic activity suggests that BN may possess therapeutic benefits to other disorders. So, the present study aims to identify the potential therapeutic targets of BN using a network pharmacological approach to comprehend the multi target action of its multiple phytoconstituents. We have employed Randić Index for the first time to calculate the contribution score of m... More

关键词

Brahmi Nei (BN), Contribution Score (CS), Randić Index, molecular modelling, network pharmacology