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Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Vaccine. 2024-01; 
Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy
Products/Services Used Details Operation
Recombinant Proteins … protein; the Spike NTD recombinant protein, and the Spike RBD recombinant protein. The … block/reduce RBD-hACE2 binding in the GenScript surrogate virus neutralization test (sVNT) (… Get A Quote

摘要

The responsiveness/cross-binding of vaccine-induced memory B cells/MBCs to previous and emerging divergent SARS-CoV-2 variants (e.g., Omicron) is understudied. In this longitudinal study subjects receiving two or three doses of monovalent ancestral strain-containing COVID-19 mRNA vaccine were evaluated. In contrast to others, we observed significantly lower frequencies of MBCs reactive to the receptor-binding domain/RBD, the N-terminal domain/NTD, and the S1 of Omicron/BA.1, compared to Wuhan and Delta, even after a 3rd vaccine dose/booster. Our study is a proof of concept that MBC cross-reactivity to variants with greater sequence divergence from the vaccine strain may be overestimated and suggests that these ... More

关键词

Antibodies, neutralizing, B cells, COVID-19, Humoral immune responses, Immunological memory, SARS-CoV-2, Vaccine, Variants of concern