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APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Cell Mol Biol Lett. 2024-06; 
Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang
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Catalog Peptides … Β-amyloid (Aβ) oligomers were prepared from human Aβ (1–42) peptide (RP10017CN, GenScript, New Jersey, USA) following a previously established protocol [31, 32]. The β-Amyloid … Get A Quote

摘要

background: Alzheimer's disease (AD) is a progressive neurodegenerative disease and apolipoprotein E (APOE) genotypes (APOE2, APOE3, and APOE4) show different AD susceptibility. Previous studies indicated that individuals carrying the APOE2 allele reduce the risk of developing AD, which may be attributed to the potential neuroprotective role of APOE2. However, the mechanisms underlying the protective effects of APOE2 is still unclear. methods: We analyzed single-nucleus RNA sequencing and bulk RNA sequencing data of APOE2 and APOE3 carriers from the Religious Orders Study and Memory and Aging Project (ROSMAP) cohort. We validated the findings in SH-SY5Y cells and AD model mice by evaluating mitochondrial functi... More

关键词

Alzheimer's disease, Apolipoprotein E, Beta-amyloid (Aβ), ESRRA, Mitochondria, Neuron