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Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

CNS Neurosci Ther. 2024-05; 
Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu
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Proteins, Expression, Isolation and Analysis … (GenScript), for 7–10 days before differentiation. Triiodothyronine (T3; R&D Systems, MN, USA) and ciliary neurotrophic factor (CNTF; GenScript… to generate a protein–protein interaction … Get A Quote

摘要

background: Adenosine A3 receptor (ADORA3) belongs to the adenosine receptor families and the role of ADORA3 in vascular dementia (VaD) is largely unexplored. The present study sought to determine the therapeutic role of ADORA3 antagonist in a mouse model of VaD. methods: The GSE122063 dataset was selected to screen the differential expression genes and pathways between VaD patients and controls. A mouse model of bilateral carotid artery stenosis (BCAS) was established. The cognitive functions were examined by the novel object recognition test, Y maze test, and fear of conditioning test. The white matter injury (WMI) was examined by 9.4 T MRI, western blot, and immunofluorescence staining. The mechanisms of A... More

关键词

Mertk, adenosine A3 receptor, microglia, phagocytosis, vascular dementia, white matter injury