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Variation in structural motifs within SARS-related coronavirus spike proteins

PLoS Pathog. 2024-05; 
Francesca R Hills, Alice-Roza Eruera, James Hodgkinson-Bean, Fátima Jorge, Richard Easingwood, Simon H J Brown, James C Bouwer, Yi-Ping Li, Laura N Burga, Mihnea Bostina
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Proteins, Expression, Isolation and Analysis … funded previous work which provided rationale for proteins selected in this study and facilitated … proteins with 3’ and 5’ flanking extensions were obtained through Genscript Hong Kong. … Get A Quote

摘要

SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information exists related to the close genetic species within the SARS-related coronaviruses. Here, we present three novel SARS-related CoV spike protein structures solved by single particle cryo-electron microscopy analysis derived from bat (bat SL-CoV WIV1) and civet (cCoV-SZ3, cCoV-007) hosts. We report complex glycan trees that decorate the glycoproteins and density for water molecules which facilitated modeling of the water molecule coordination networks within structurally important regions. We note structural conservation of the fatty acid binding pocket and prese... More

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