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Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression

Chem Biol Drug Des. 2024-01; 
Pengfei Kong, Xuemei Tang, Fang Liu, Xuegui Tang
Products/Services Used Details Operation
Custom DNA/RNA Oligos GenScript (Nanjing, China). Also, miR-873-5p mimic/inhibitor (miR-873-5p/anti-miR-873-5p), circ_0001615-specific small interfering RNA (si-circ_0001615), and their corresponding … Get A Quote

摘要

Astragaloside IV (AS-IV) has exhibited pivotal anti-cancer efficacy in multiple types of cancer, including colorectal cancer (CRC). Meanwhile, circular RNA (circRNA) circ_0001615 has been reported to be involved in the malignant development of CRC. Herein, this study is expected to figure out the interaction between circ_0001615 and AS-IV on CRC progression. The 50% inhibition concentration (IC50), proliferation, apoptosis, and migration were detected by Cell Counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), flow cytometry, and wound healing assays. The expression of related proteins was examined by western blot. Circ_0001615, microRNA-873-5p (miR-873-5p), and LIM and SH3 protein 1 (LASP1) levels were de... More

关键词

AS-IV, circ_0001615, miR-873-5p, migration, proliferation