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Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024-08; 
Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song
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Peptide Synthesis ...The NE-cleavable peptide, N-acetyl-Ala-Ala-Pro-Val-COOH, was obtained from GenScript Corporation and coupled with compound 3 to form compound 4... Get A Quote

摘要

Atherosclerosis is a primary global health concern due to its high morbidity and mortality. This disease is characterized by a complex interplay of chronic inflammation, oxidative stress, and proteolytic enzymes. Traditional imaging techniques struggle to capture the dynamic biochemical processes within atherosclerotic plaques. Herein, we have developed a novel unimolecular photoacoustic probe (UMAPP) that combines specific recognition sites for neutrophil elastase (NE) and the redox pair O2•‒/GSH into a cohesive molecular platform, allowing in vivo monitoring of oxidative stress and activated neutrophils within plaques. UMAPP features a boron-dipyrromethene (BODIPY) core linked to a hydrophilic NE-cleavabl... More

关键词

Atherosclerosis; neutrophil elastase; oxidative stress; photoacoustic imaging; simultaneous detection.