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Amplifiable protein identification via residue-resolved barcoding and composition code counting

National Science Review. 2024-05; 
Weiming Guo , Yuan Liu , Yu Han , Huan Tang , Xinyuan Fan , Chu Wang , Peng R Chen
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摘要

Ultrasensitive protein identification is of paramount importance in basic research and clinical diagnostics but remains extremely challenging. A key bottleneck in preventing single-molecule protein sequencing is that, unlike the revolutionary nucleic acid sequencing methods that rely on the polymerase chain reaction (PCR) to amplify DNA and RNA molecules, protein molecules cannot be directly amplified. Decoding the proteins via amplification of certain fingerprints rather than the intact protein sequence thus represents an appealing alternative choice to address this formidable challenge. Herein, we report a proof-of-concept method that relies on residue-resolved DNA barcoding and composition code counting for ... More

关键词

DNA barcoding; amplifiable fingerprinting; composition code counting; protein identification; residue-specific chemistry.